Longmore Lab Publications

Bayer SVH, Grither WR, Brenot A, Hwang PY, Barcus CE, Ernst M, Pence P, Walter C, Pathak A, Longmore GD. (2019) DDR2 controls breast tumor stiffness and metastasis by regulating Integrin mediated mechanotransduction in CAFs. eLife. https://elifesciences.org/articles/45508

Hwang PY, Brenot A, King AC, Longmore GD, George SC. (2019) Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues. Cancer Res. 79(8):1899-1912. http://cancerres.aacrjournals.org/content/79/8/1899.long

Grither WR, Longmore GD. (2018) Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain.  Proc Natl Acad Sci U S A. 115(33):E7786-E7794. https://www.pnas.org/content/115/33/E7786.long

Brenot A, Knolhoff BL, DeNardo DG, Longmore GD. (2018) SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion. Oncogenesis. 7(3):32. https://www.nature.com/articles/s41389-018-0042-x

Grither WR, Divine LM, Meller EH, Wilke DJ, Desai RA, Loza AJ, Zhao P, Lohrey A, Longmore GD, Fuh KC. (2018) TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis. Oncogene. 37(13):1714-1729. https://www.nature.com/articles/s41388-017-0043-9

Sewell-Loftin MK, Bayer SVH, Crist E, Hughes T, Joison SM, Longmore GD, George SC. (2017) Cancer-associated fibroblasts support vascular growth through mechanical force. Sci Rep. 7(1):12574. https://www.nature.com/articles/s41598-017-13006-x

Loza AJ, Koride S, Schimizzi GV, Li B, Sun SX, Longmore GD. (2016) Cell density and actomyosin contractility control the organization of migrating collectives within an epithelium. Mol Biol Cell. 27(22):3459-3470. https://www.molbiolcell.org/doi/full/10.1091

Biswas H, Longmore GD. (2016) Action of SNAIL1 in Cardiac Myofibroblasts Is Important for Cardiac Fibrosis following Hypoxic Injury. PLoS One. 11(10):e0162636. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162636

Jagannathan R, Schimizzi GV, Zhang K, Loza AJ, Yabuta N, Nojima H, Longmore GD. (2016) AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol. Mol Cell Biol. 36(20):2526-42. https://mcb.asm.org/content/36/20/2526.long

Schimizzi GV, Maher MT, Loza AJ, Longmore GD. (2016) Disruption of the Cdc42/Par6/aPKC or Dlg/Scrib/Lgl Polarity Complex Promotes Epithelial Proliferation via Overlapping Mechanisms. PLoS One. 11(7):e0159881. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159881

Corsa CA, Brenot A, Grither WR, Van Hove S, Loza AJ, Zhang K, Ponik SM, Liu Y, DeNardo DG, Eliceiri KW, Keely PJ, Longmore GD. (2016) The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis. Cell Rep. 15(11):2510-23. https://www.sciencedirect.com/science/article

Zhang K, Grither WR, Van Hove S, Biswas H, Ponik SM, Eliceiri KW, Keely PJ, Longmore GD. (2016) Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts. J Cell Sci. 129(10):1989-2002. http://jcs.biologists.org/content/129/10/1989.long

Schimizzi GV, Longmore GD. (2015) Ajuba proteins. Curr Biol. 25(11):R445-6. https://www.sciencedirect.com/science/article

Tran HD, Luitel K, Kim M, Zhang K, Longmore GD, Tran DD. (2014) Transient SNAIL1 expression is necessary for metastatic competence in breast cancer. Cancer Res. 74(21):6330-40. http://cancerres.aacrjournals.org/content/74/21/6330.long

Yashiro H, Loza AJ, Skeath JB, Longmore GD. (2014) Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II. Mol Biol Cell. 25(19):2956-69. https://www.molbiolcell.org/doi/full/10.1091

Bajpai, S., Y. Feng, D. Wirtz, G.D. Longmore. (2013).  B-catenin serves as a clutch between low and high intercellular E-cadherin bond strengths. Biophys J. 105(10):2289-300. http://www.sciencedirect.com/science/article/pii/S0006349513011181

Giri A, Bajpai S, Trenton N, Jayatilaka H, Longmore GD, Wirtz D. (2013).  The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration. FASEB J. Oct;27(10):4089-4099. http://www.fasebj.org/content/27/10/4089.long

Zhang K., C. Corsa, S. Ponik, J. Prior, D. Piwnica-Worms, K. Eliceiri, P. Keely, and G.D. Longmore. (2013). The Collagen Receptor Discoidin Domain Receptor 2 Stabilizes Snail1 Protein to Facilitate Breast Cancer Metastasis.  Nat. Cell Biol. Jun;15(6):677-87. http://www.nature.com/ncb/journal/v15/n6/full/ncb2743.html

Feng Y, H. Ngu, S. Alford, M. Ward, F. Yin, and G.D. Longmore. (2013).  α-Actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation. Exp Cell Res. 319(8):1124-35. http://www.sciencedirect.com/science/article/pii/S0014482713000657

Chambliss AB, S. Khatau, N. Erdenberger, D. Robinson, D. Hodzic, G.D. Longmore, and D. Wirtz. (2013). The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction.
Sci Rep. 3:1087. http://www.nature.com/srep/2013/130118/srep01087/full/srep01087.html

Kim D.H, S. Khatau, Y. Feng, S. Walcott, S. Sun, G.D. Longmore, and D. Wirtz. (2012).  Actin cap associated focal adhesions and their distinct role in cellular mechanosensing. Sci Rep. 2:555. http://www.nature.com/srep/2012/120803/srep00555/full/srep00555.html

Lee MH, Wu PH, Staunton JR, Ros R, Longmore GD, Wirtz D. (2012). Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer.
Biophys J. Jun 20;102(12):2731-41. http://www.sciencedirect.com/science/article/pii/S0006349512005577

Fraley, S.I., Y. Feng, A. Giri, G.D. Longmore and D. Wirtz. (2012). Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nat. Commun. Mar 6;3:719. http://www.nature.com/ncomms/journal/v3/n3/full/ncomms1711.html - G. Longmore, communicating author

Foxler, D.E., K. Bridge, V. James, T. Webb, M. Mee, S. Wong, Y. Feng, T. Petursdottir, J. Bjornsson, S. Ingvarsson, P.J. Ratcliffe, G.D. Longmore and T.V. Sharp. (2012).  The LIMD1 protein bridges an association between the Prolyl Hydroxylases and VHL to repress HIF1 activity. Nat. Cell Biol. Jan 29;14(2):201-8. http://www.nature.com/ncb/journal/v14/n2/full/ncb2424.html

Nola, S., R. Daigaku, K. Smolarczyk , M. Carstens , B. Martin-Martin, G. Longmore,  M. Bailly and V.M.M. Braga. (2011).  Ajuba is required for Rac activation and maintenance of E-cadherin adhesion.  
J. Cell. Biol. Nov 28;195(5):855-71. http://jcb.rupress.org/content/195/5/855.long

Tran, D.G., C.A.S. Corsa, H. Biswas, R.L. Aft, and G.D. Longmore. (2011).  Temporal and Spatial cooperation of Snail1 and Twist1 during Epithelial-Mesenchymal Transition predicts for human breast cancer recurrence.
Mol. Cancer Res. Dec;9(12):1644-57. Epub 2011 Oct 17. http://mcr.aacrjournals.org/content/9/12/1644.long

Zhang, K., E. Rodriguez-Aznar, N. Yabuta, R.J. Owen, J.M. Mingot, H. Nojima, M.A. Nieto, and G.D. Longmore.  (2011).  Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.  
EMBO J., Sep 27;31(1):29-43. doi: 10.1038/emboj.2011.357. http://emboj.embopress.org/content/31/1/29.long

Fraley SI, Feng Y, Krishnamurthy R, Kim DH, Celedon A, Longmore GD, Wirtz D. (2010) A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol. 12(6):598-604. https://www.nature.com/articles/ncb2062

Feng, Y., L. Nie, M. Das Thakur, Q. Su, Z. Chi, Y. Zhao, and G.D. Longmore. (2010).  A multifunctional lentiviral-based gene knockdown with concurrent rescue that controls for off-target effects of RNAi.  
Genomics Proteomics Bioinformatics 8(4): 238-45. http://www.sciencedirect.com/science/article/pii/S1672022910600253

Warner, S.J. and G.D. Longmore. (2010).  Context dependent compensatory proliferation in epithelial homeostasis and tumorigenesis.  Cell Cycle 9(20):4037. https://www.landesbioscience.com/journals/cc/article/13562/

James, V., Y. Zhang, D.E. Foxler, C.H. de Moor, Y.W. Kong, T.M. Webb, T.J. Self, Y. Feng, D. Lagos, C.Y. Chu, T.M. Rana, S.J. Morley, G.D. Longmore, M. Bushell and T.V. Sharp. (2010).  LIM-domain proteins LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.   Proc Natl Acad Sci U S A. 107(28):12499-504. http://www.pnas.org/content/107/28/12499.long

Fraley, S., Y. Feng, R. Krishnamurthy, D. Kim, G.D. Longmore and D. Wirtz. (2010).  A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat. Cell Biol. 12(6):598-604. http://www.nature.com/ncb/journal/v12/n6/full/ncb2062.html   - G. Longmore, communicating author

Warner, S.J., H. Yashiro and G.D. Longmore. (2010).  The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia.  Curr. Biol. April 7. http://www.sciencedirect.com/science/article/pii/S0960982210003453

 Alford, S.K., Y. Wang, Y. Feng, G.D. Longmore and D.L. Elbert. (2010).  Prediction of Sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements. Ann Biomed Eng. 38(8):2775-90. http://link.springer.com/article/10.1007%2Fs10439-010-0014-6

Das Thakur M, Feng Y, Jagannathan R, Seppa MJ, Skeath JB, Longmore GD. (2010) Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol. 20(7):657-62. https://www.sciencedirect.com/science/article

Hou, Z., H. Peng, D.G. Negorev, G.G. Maul, Y. Feng, G.D. Longmore, S. Waxman, A. Zelent, and F.J. Rauscher.  (2010).  The LIM protein Ajuba functions as a nuclear receptor co-repressor and negatively regulates retinoic acid signaling.  Proc. Natl. Acad. Sci (USA) 107(7):2938-43 http://www.pnas.org/content/107/7/2938.long

Ngu, H., Y. Feng, L. Lu, S.J. Oswald, G.D. Longmore and F.C Yin. (2010). Effect of focal adhesion proteins on endothelial cell adhesion, motility and orientation response to cyclic strain. Ann. Biomed. Eng. 38(1):208-22 http://link.springer.com/article/10.1007%2Fs10439-009-9826-7

Warner, S.J. and G.D. Longmore. (2009).  Cdc42 Antagonizes Rho1 Activity at Adherens Junctions to Limit Epithelial Cell Apical Tension.  J. Cell Biol. 187(1):119-33 http://jcb.rupress.org/content/187/1/119.long

Hadland, B.K., and G.D. Longmore. (2009).  Erythroid-Stimulating Agents in Cancer Therapy: Potential Dangers and Biologic Mechanisms.  J. Clin. Oncol. 27(25):4217-26. http://jco.ascopubs.org/content/27/25/4217.long

Warner, S.J., and G.D. Longmore. (2009).  Distinct Functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epithelia.  J. Cell Biol.  185(6):111-25. http://jcb.rupress.org/content/185/6/1111.long

Bajpai, S., Y. Feng, R. Krishnamurthy, G.D, Longmore, D. Wirtz. (2009).  Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells.  J. Biol. Chem. 284(27):18252-9. http://www.jbc.org/content/284/27/18252.long

Schindler, E.M., A. Hindes, E.L. Gribben, C.J. Burns, Y. Yin, M.H. Lin, R.J. Owen, G.D. Longmore, G.E. Kissling, J.S. Arthur, T. Efimova. (2009). p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.  Cancer Res. 69(11):4648-55. http://cancerres.aacrjournals.org/content/69/11/4648.long

Montoya-Durango, D.E., C.S. Velu, A. Kazanjian, M.E.B. Rojas, C.M. Jay, G.D. Longmore, and H.L. Grimes.  (2008).  Ajuba functions as an HDAC-dependent co-repressor for autoregulation of the growth factor independent-1 transcription factor.  J. Biol. Chem. 283(46):32056-65. http://www.jbc.org/content/283/46/32056.long

Bajpai, S., J. Correia, Y. Feng, J. Figueiredo, S.X. Sun, G.D. Longmore, G. Suriano, and D. Wirtz. (2008).  Alpha-catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening. Proc. Natl. Acad. Sci. (USA) 105(47):18331-6. http://www.pnas.org/content/105/47/18331.long

Sharp, T.V., A. Al-Attar, L. Ding, D.E. Foxler, T.Q. de A. Vallim, Y. Zhang, H.S. Nijmeh, T.M. Webb, A.G. Nicholson, Q. Zhang, A. Kraja, I. Spendlove, J. Osborne, E. Mardis, and G.D. Longmore. (2008).  The chromosome 3p21.3 encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.  Proc. Natl. Acad. Sci. (USA) 105(50):19932-7. http://www.pnas.org/content/105/50/19932.long

Luderer, H.F., S. Bai and G.D. Longmore.  (2008).  The LIM protein LIMD1 influences osteoblast differentiation and function. Exp. Cell Res. 314(15):2884-94. http://www.sciencedirect.com/science/article/pii/S0014482708002334

Spendlove, I., A. Al-Attar, O. Watherstone, T.M. Webb, I.O. Ellis, G.D. Longmore, and T.V. Sharp. (2008).  Differential subcellular localization of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival.  Int. J. Cancer 123(10):2247-53. http://onlinelibrary.wiley.com/doi/10.1002/ijc.23851/abstract

Alford, S.K., G.D. Longmore, W.F. Stenson, and C. Kemper. (2008).  CD46-induced immunomodulatory CD4+ T cells express the adhesion molecule and chemokine receptor pattern of intestinal T cells. J. Immunology 181(4):2544-55. http://www.jimmunol.org/content/181/4/2544.long

Epple, H., V. Cremasco, D. Mao, G.D. Longmore and R. Faccio.  (2008).  PLCgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. Mol. Cell. Biol. 28(11):3610-22. http://mcb.asm.org/content/28/11/3610.long G. Longmore communicating author

Zhaoyuan, H, H. Peng, K. Ayyanathan, K. Yan, E.M. Langer, G.D. Longmore, and F.J. Rauscher III. (2008).  The LIM protein Ajuba recruits protein arginine methyltransferase 5 (PRMT5) to mediate Snail-dependent transcriptional repression.  Mol. Cell. Biol. 28(10):3198-207. http://mcb.asm.org/content/28/10/3198.long

Langer, E.M., Y. Feng, H. Zhaoyuan, F.J. Rauscher III, K.K. Kroll and G.D. Longmore. (2008).  Ajuba LIM proteins are Snail/Slug corepressors required for neural crest development in Xenopus.  Developmental Cell 14(3):424-36. http://www.sciencedirect.com/science/article/pii/S1534580708000336

Lu, L., Y. Feng, W.J. Hucker, S.J. Oswald, G.D. Longmore, and F.C-P. Yin. (2008).  Actin stress fiber pre-extension in human aortic endothelial cells.  Cell Motility Cytoskeleton 65(4):281-94. http://onlinelibrary.wiley.com/doi/10.1002/cm.20260/abstract;jsessionid=919D7AC183376648FC38CFEE101E3EA9.f01t03

Wacker, B.K., S.K. Alford, E.A. Scott, M. Das Thakur, G.D Longmore, and D.L. Elbert. (2008).  Optimizing RGD peptide concentration for endothelial cell migration on S1P releasing PEG hydrogels.  Biophys. J. 94(1):273-85. http://www.sciencedirect.com/science/article/pii/S0006349508707860

Giurosato, E., Cella, M., Takai, T., Kurosaki, T, Feng, Y., Longmore, G.D., Colonna, M., and Shaw, A.S. (2007).  PI3-kinase activation is required to form the NKG2D immunological synapse. Mol. Cell. Biol. 27(24):8583-99. http://mcb.asm.org/content/27/24/8583.long

Ayyanathan, K., H. Peng, H. Zhouyuan, W.J. Fredericks, R.K. Goyal, E.M. Langer, G.D. Longmore, and F.J. Rauscher III.  (2007).  Functional analysis of the SNAG repression domain from the GFI-1 proto-oncogene: LIM domain proteins as mediators of SNAG repression. Cancer Res. 67(19):9097-106. http://cancerres.aacrjournals.org/content/67/19/9097.long

Longmore, G.D. (2007).  Do cancer cells express functional erythropoietin receptors?  N Engl J Med. 356(24):2447. http://www.nejm.org/doi/full/10.1056/NEJMp078112

Feng, Y., H. Zhao, H. Luderer, H. Epple, R. Faccio, F.P. Ross, S.L. Teitelbaum, and G.D. Longmore. (2007).  The LIM protein, LIMD1, regulates AP-1 activation through an interaction with TRAF6 to influence bone osteoclast development.  J. Biol. Chem. 282(1), 39-38. http://www.jbc.org/content/282/1/39.long

Longmore, G.D. (2006). A unique role for Stat5 in recovery from acute anemia.  J Clin Invest 116:626-8. http://www.jci.org/articles/view/27988

Jones, K.B., D.W. Anderson, and G.D. Longmore. (2005). Effects of recombinant hematopoietins on blood-loss anemia in mice.  Iowa Orthop. J. 25:129-34. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888772/

Feng, Y., and G.D. Longmore. (2005). The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. Mol. Cell. Biol. 25:4010-22. http://mcb.asm.org/content/25/10/4010.long

Kisseleva, M., Y. Feng, M. Ward, C. Song, R.A. Anderson, and G.D. Longmore. (2005). The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. Mol. Cell. Biol. 25:3956-66. http://mcb.asm.org/content/25/10/3956.long

Pratt, S.J., H. Epple, M. Ward, Y. Feng, V.M. Braga, and G.D. Longmore. (2005). The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J. Cell Biol. 168:813-24. http://jcb.rupress.org/content/168/5/813.long

Hadland, B.K., S.S. Huppert, J. Kanungo, Y. Xue, R. Jiang, T. Gridley, R.A. Conlon,
A.M. Cheng, R. Kopan, and G.D. Longmore. (2004). A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood 104:3097-105. http://www.bloodjournal.org/content/104/10/3097.long?sso-checked=true

Young, A.P., and G.D. Longmore. (2004). Differential regulation of apoptotic genes by Rb in human versus mouse cells. Oncogene 23:2587-99. http://www.nature.com/onc/journal/v23/n15/full/1207330a.html

Young, A.P., and G.D. Longmore. (2004). Differences in stability of repressor complexes at promoters underlie distinct roles for Rb family members. Oncogene 23:814-23. http://www.nature.com/onc/journal/v23/n3/full/1207187a.html

Young, A.P., and G.D. Longmore. (2004). Ras protects Rb family null fibroblasts from cell death: a role for AP-1.  J. Biol. Chem. 279:10931-8. http://www.jbc.org/content/279/12/10931.long