The 2015 STARS (Students and Teachers As Research Scientists) program wrapped up with Pradeep Kandula and Melany Yueng presenting the results of their six-week projects. Both students examined the multidrug resistance (MDR) Pgp (P-glycoprotein) substrate status of compounds designed for imaging of neurodegenerative diseases.
Kevin Wernke completed his Amgen Scholar summer research. During which, he synthesized new molecules designed to bind with Aβ (β-amyloid) plaques for the purpose of developing new Alzheimer's disease imaging agents.
Jothilingam Sivapackiam and GSM Sundaram presented their work at the annual SNMMI (Society of Nuclear Medicine and Molecular Imaging) in Boston. Jothi presented a poster discussing the use of Galmydar for myocardial perfusion imaging. Sundaram gave a talk on the develpoment of a novel Aβ plaque imaging agent.
Scott Harpstrite and GSM Sundaram attended the 21st ISRS (International Symposium on Radiopharmaceutical Sciences) in Columbia MO. Scott presented a poster on his research involving monitoring of BCRP (breast cancer resistance protein) functional transport. Sundaram presented a poster showing his work on the design and synthesis of new agents for imaging of Aβ plaques.
GSM Sundaram's paper "Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer's disease." is available online: free PMC article
"A Generator-Produced Gallium-68 Radiopharmaceutical for PET Imaging of Myocardial Perfusion" is available online: free PMC article
Amgen Scholar Laken Kendrick completed her summer research on the cellular accumulation of newly developed heterocyclic compounds and their toxicity on carcinoma cells.
The 2014 STARS (Students and Teachers As Research Scientists) program concluded successfully. Claire Munsell presented the results of her summer project on the cellular accumulation of a newly developed compound in glioma cells. Stephen Mattingly presented his work examining the feasibility of monitoring of the basal expression and functionality of multidrug resistance (MDR) transporters Pgp (P-glycoprotein) and BCRP (breast cancer resistance protein).
GSM Sundaram gave two talks at the annual SNMMI (Society of Nuclear Medicine and Molecular Imaging) meeting, this year held in downtown St. Louis. He presented results of the design and synthesis of a novel Aβ plaque imaging agent and work on the use of live cell imaging to monitor function Pgp (P-glycoprotein) expression.