DeNardo Lab Publications

Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer. Grossman JG, Nywening TM, Belt BA, Panni RZ, Krasnick BA, DeNardo DG, Hawkins WG, Goedegebuure SP, Linehan DC, Fields RC. Oncoimmunology. 2018 Aug 1

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance. Meyer MABaer JMKnolhoff BLNywening TMPanni RZSu XWeilbaecher KNHawkins WGMa CFields RCLinehan DCChallen GAFaccio RAft RLDeNardo DG. Nature Communications. 2018 Mar 28.

SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion. Brenot AKnolhoff BLDeNardo DGLongmore GD. Oncogenesis. 2018 Mar 29.

Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma. Nywening TMBelt BA,...Fields RCDeNardo DGHawkins WGGoedegebuure PLinehan DCGut. 2017 Dec 1.

Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoesis and promote tumor progression. Zhu, Y, Herndon, JM,...Randolph, GJ, DeNardo DGImmunity, Volume 47, Issue 2, 2017 Aug 15

Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy. Jiang H, Hegde S, DeNardo DGCancer Immunol Immunother. 2017 Apr 27. 

Constitutive IRAK4 Activation Underlies Poor Prognosis And Chemoresistance In Pancreatic Ductal Adenocarcinoma. Zhang D, Li L, Jiang H, Knolhoff B, Lockhart AC, Wang-Gillam A, DeNardo DG, Ruzinova MB, Lim KHClin Cancer Res. 2016 Oct 4.

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy. Jiang H, Hegde S, Knolhoff BL, Zhu Y, Herndon JM, Meyer MA, Nywening TM, Hawkins WG, Shapiro IM, Weaver DT, Pachter JA, Wang-Gillam A, DeNardo DGNature Medicine. 2016 Jul 4.

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis. Ruhland MK, Loza AJ, Capietto AH, Luo X, Knolhoff BL, Flanagan KC, Belt BA, Alspach E, Leahy K,Luo J, Schaffer A, Edwards JR, Longmore G, Faccio R, DeNardo DG, Stewart SANat Commun. 2016 Jun 8;7:11762.

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis. Corsa CA, Brenot A, Grither WR, Van Hove S, Loza AJ, Zhang K, Ponik SM, Liu Y, DeNardo DG,Eliceiri KW, Keely PJ, Longmore GDCell Rep. 2016 Jun 14;15(11):2510-23.

Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic. Ohman KA, Hashim YM, Vangveravong S, Nywening TM, Cullinan DR, Goedegebuure SP, Liu J, Van Tine BA, Tiriac H, Tuveson DA, DeNardo DG, Spitzer D, Mach RH, Hawkins WGOncotarget. 2016 May 22.

Antagonizing Integrin β3 Increases Immunosuppression in Cancer. Su X, Esser AK, Amend SR, Xiang J, Xu Y, Ross MH, Fox GC, Kobayashi T, Steri V, Roomp K,Fontana F, Hurchla MA, Knolhoff BL, Meyer MA, Morgan EA, Tomasson JC, Novack JS, Zou W,Faccio R, Novack DV, Robinson SD, Teitelbaum SL, DeNardo DG, Schneider JG, Weilbaecher KNCancer Res. 2016 Jun 15;76(12):3484-95

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial. Nywening TM, Wang-Gillam A, Sanford DE, Belt BA, Panni RZ, Cusworth BM, Toriola AT, Nieman RK,Worley LA, Yano M, Fowler KJ, Lockhart AC, Suresh R, Tan BR, Lim KH, Fields RC, Strasberg SM,Hawkins WG, DeNardo DG, Goedegebuure SP, Linehan DCLancet Oncol. 2016 May;17(5):651-62.

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer. D'Amico L, Mahajan S, Capietto AH, Yang Z, Zamani A, Ricci B, Bumpass DB, Meyer M, Su X, Wang-Gillam A, Weilbaecher K, Stewart SA, DeNardo DG, Faccio RJ Exp Med. 2016 May 2;213(5):827-40.

Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis. Demehri S, Cunningham TJ, Manivasagam S, Ngo KH, Moradi Tuchayi S, Reddy R, Meyers MADeNardo DG, Yokoyama WMJ Clin Invest. 2016 Apr 1;126(4):1458-70.

TH2-Polarized CD4(+) T Cells and Macrophages Limit Efficacy of Radiotherapy. Shiao SL, Ruffell B, DeNardo DG, Faddegon BA, Park CC, Coussens LMCancer Immunol Res. 2015 May;3(5):518-25. 

CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T cell checkpoint immunotherapy in pancreatic cancer models.
Zhu Y, Knolhoff BL, Meyer MA, Nywening TM, West BL, Luo J, Wang-Gillam A, Goedegebuure SP, Linehan DC, DeNardo DG
 Cancer Res 2014 Jul 31

Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer.
Panni RZ, Sanford DE, Belt BA, Mitchem JB, Worley LA, Goetz BD, Mukherjee P, Wang-Gillam A, Link DC, DeNardo DG, Goedegebuure SP, Linehan DC 
Cancer Immunol Immunother 2014 May;63(5):513-28

Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models
Zhong H, Sanchez C, Spitrzer D, Plambeck-Suess S, Gibbs J, Hawkins WG, DeNardo DG, Gao F, Pufahl RA, Lockhart AC, Xu M, Linehan D, Weber J, Wang-Gillam A 
PLoS One 2013 Oct 9;8(10):e77243

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.
Ruffell B, Affara NI, Cottone L, Junankar S, Johansson M, DeNardo DG, Korets L, Reinheckel T, Sloane BF, Bogyo M, Coussens LM
 Genes Dev 2013 Oct 1;27(19):2086-98

Targeting tumor-infiltrating macrophages to combat cancer.
Panni RZ, Linehan DC, DeNardo DG 
Immunotherapy 2013 Oct;5(10):1075-87

A study of zoledronic acid as neo-adjuvant, perioperative therapy in patients with resectable pancreatic ductal adenocarcinoma.
Sanford DE, Porembka MR, Panni RZ, Mitchem JB, Belt BA, Plambeck-Suess SM, Lin G, DeNardo DG, Fields RC, Hawkins WG, Strasberg SM, Lockhart AC, Wang-Gillam A, Goedegebuure SP, Linehan DC 
J Cancer Ther 2013 May;4(3):797-803

Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis.
Sanford DE, Belt BA, Panni RZ, Mayer A, Deshpande AD, Carpenter D, Mitchem JB, Plambeck-Suess SM, Worley LA, Goetz BD, Wang-Gillam A, Eberlein TJ, DeNardo DG, Goedegebuure SP, Linehan DC
 Clin Cancer Res 2013 Jul 1;19(13):3404-15

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.
Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG Cancer Res 2013 Feb 1;73(3):1128-1141

Tumor-infiltrating macrophages, cancer stem cells and therapeutic responses.
Panni RZ, Linehan DC,DeNardo DGOncotarget 2012 Dec;3(12):1497-8

Battle over CCL2 for control of the metastatic niche: neutrophils versus monocytes.
Mitchem JB, DeNardo DGBreast Cancer Res 2012 Jul 19;14(4):315

MRI of tumor-associated macrophages with clinically applicable iron oxide nanoparticles.
Daldrup-Link HE, Golovko D, Ruffell B,DeNardo DG, Castaneda R, Ansari C, Rao J, Tikhomirov GA, Wendland MF, Corot C, Coussens LM
 Clin Cancer Res 2011 Sep 1;17(17):5695-704

Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.
 DeNardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, Madden SF, Gallagher WM, Wadhwani N, Keil SD, Junaid SA, Rugo HS, Hwang ES, Jirstrom K, West BL, Coussens LM
 Cancer Discov 2011 Jun 1;1:54-67

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity. DeNardo DG, Andreu P, Coussens LM
 Cancer Metastasis Rev 2010 Jun;29(2):309-16

FcRgamma activation regulates inflammation-associated squamous carcinogenesis.
Andreu P, Johansson M, Affara NI, Pucci F, Tan T, Junankar S, Korets L, Lam J, Tawfik D, DeNardo DG, Naldini L, de Visser KE, De Palma M, Coussens LM
 Cancer Cell 2010 Feb 17;17(2):121-34

Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression.
Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens LM, Karin M, Goldrath AW, Johnson RS
 Cancer Res 2010 Oct 1;70(19):7465-75

Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response.
Ursini-Siegel J, Cory S, Zuo D, Hardy WR, Rexhepaj E, Lam S, Schade B, Jirstrom K, Bjur E, Piccirillo CA, DeNardo DG, Coussens LM, Brennan DJ, Gallagher WM, Park M, Pawson T, Hallett M, Muller WJ
 Cancer Res 2010 Oct 15;70(20):7776-87

Labeling human embryonic stem cell-derived cardiomyocytes with indocyanine green for noninvasive tracking with optical imaging: an FDA-compatible alternative to firefly luciferase.
Boddington SE, Henning TD, Jha P, Schlieve CR, Mandrussow L, DeNardo DG, Bernstein HS, Ritner C, Golovko D, Lu Y, Zhao S, Daldrup-Link HE

Cell Transplant 2010;19(1):55-65

Lymphocytes in cancer development: polarization towards pro-tumor immunity.
Ruffell B, DeNardo DG, Affara NI, Coussens LM
 Cytokine Growth Factor Rev 2010 Feb;21(1):3-10

Optical imaging of the peri-tumoral inflammatory response in breast cancer.
Sista AK, Knebel RJ, Tavri S, Johansson M, DeNardo DG, Boddington SE, Kishore SA, Ansari C, Reinhart V, Coakley FV, Coussens LM, Daldrup-Link HE
 J Transl Med 2009 Nov 11;7:94

CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.
 DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM
 Cancer Cell 2009 Aug 4;16(2):91-102