Weber Lab Publications

Yuan B., Wang X., Fan C., Yu J., Liu Y. Weber J.D., Zongand H., and Zhang Y. (2016). DHX33 transcriptionally controls genes involved in cell cycle. Molecular and Cellular Biology, in press.
http://mcb.asm.org/content/early/2016/08/30/MCB.00314-16.long

Weber J.D., Yarden Y., Dustin M., Sassoon D.A., and Ezekowitz A. (2015). Functional Cell Biology: An Overview. Encyclopedia of Cell Biology, 3: 1-7, Waltham, MA: Academic Press.

Maggi L.B. and Weber J.D. (2015). Targeting PTEN-deficient breast cancers with a one-two punch. Breast Cancer Research, 17:51-52.
http://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0566-3

Zhang Y., You J., Wang X., and Weber J.D. (2015). The DHX33 RNA helicase promotes mRNA translation initiation. Molecular and Cellular Biology, 35:2918-31.
http://mcb.asm.org/content/35/17/2918.long

Zhang Y., Baysac K.C., Yee L.F., Saporita A.J., and Weber J.D. (2014). Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers. Breast Cancer Research, 16:449-467.
http://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-014-0449-z

Govindan R. and Weber J.D. (2014) TP53 mutations and lung cancer: not all mutations are created equal. Clinical Cancer Research, 20:4419-21.
http://clincancerres.aacrjournals.org/content/early/2014/06/10/1078-0432.CCR-14-0899.long

Maggi, L.B., Winkeler C.L., Miceli A.P., Brady S.N., Kuchenreuther M.J., and Weber J.D. (2014).  ARF tumor suppression in the nucleolus.  Biochimica et Biophysica Acta, 1842:831-839.
http://www.sciencedirect.com/science/article/pii/S0925443914000325

Forys J.T., Kuzmicki C.E., Saporita A.J., Winkeler C.L., Maggi L.B., and Weber J.D. (2014).  Arf and p53 coordinate tumor suppression of an oncogenic IFN--STAT1-ISG15 signaling axis.  Cell Reports, 7:514-26.
http://www.sciencedirect.com/science/article/pii/S2211124714002046

Kuchenruether M.J. and Weber J.D. (2014).  The ARF tumor suppressor controls Drosha translation to prevent Ras-driven transformation.  Oncogene, 33: 300-307.
http://www.nature.com/onc/journal/v33/n3/full/onc2012601a.html

Maggi L.B. and Weber J.D. (2013).  Forget transcription: translation is where the action is.  Molecular and Cellular Biology, 33:1884-5.
http://mcb.asm.org/content/33/10/1884.long

Chang C.H., Curtis J.D., Maggi L.B., Faubert B., Villarino A.V., O’Sullivan D., Huang S.C., van der Windt G.J., Blagih J., Qiu J. Weber J.D., Pearce E.J., Jones R.G. and Pearce E.L. (2013).  Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell, 153: 1239-51.
http://www.sciencedirect.com/science/article/pii/S0092867413005825

Zhong H., Sanchez C., Spitrzer D., Plambeck-Suess S., Gibbs J., Hawkins W.G., Denardo, D. Gao F., Pufahl R.A., Lockhart A.C., Xu M., Linehan D., Weber J.D., and Wang-Gillam A. (2013). Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models. PLoS One, 8: e77243.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0077243

Zhang Y., Saporita A.J., and Weber J.D. (2013). P19ARF and RasV12 offer opposing regulation of DHX33 translation to dictate tumor cell fate.  Molecular and Cellular Biology, 33: 1594-607.
http://mcb.asm.org/content/33/8/1594.long

Winkeler C.L., Kladney R.D., Maggi L.B. and Weber J.D. (2012).  Cathepsin K-Cre causes unexpected germline deletion of genes in mice.  PLoS One, 7: e42005.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042005

Ellis, M.J. et al. (2012).  Whole-genome analysis informs breast cancer response to aromatase inhibition.  Nature, 486: 353-360.
http://www.nature.com/nature/journal/v486/n7403/full/nature11143.html

Xu Z., Joshi N., Agarwal A., Dahiya S., Bittner P., Smith E., Taylor S., Piwnica-Worms D., Weber J.D. and Leonard J.R. (2012).  Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest.  Journal of Neurooncology, 108: 59-67.
http://link.springer.com/article/10.1007%2Fs11060-012-0827-2

Weber J.D. and Gutmann D.H. (2012).  Deconvoluting mTOR biology.  Cell Cycle, 11: 236-48.
https://www.landesbioscience.com/journals/cc/article/19022/

Miceli A.P., Saporita A.J., and Weber J.D. (2012).  Hyper-growth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint.  Molecular and Cellular Biology, 32: 348-64.
http://mcb.asm.org/content/32/2/348.long

Wang J., Zhang K., Grabowska D., Li A., Dong Y., Day R., Humphrey P., Lewis J.S., Kladney R., Arbeit J.M., Weber J.D., Chung C.H. and Michel L.S. (2011).  Loss of Trop2 promotes carcinogenesis and features of epithelial to mesenchymal transition in squamous cell carcinoma.  Molecular Cancer Research, 9: 1686-95.
http://mcr.aacrjournals.org/content/9/12/1686.long

Zhang Y., Forys J.T., Miceli A.P., Gwinn A.S. and Weber J.D. (2011).  Identification of DHX33 as a mediator of rRNA synthesis and cell growth.  Molecular and Cellular Biology, 31: 4676-91.
http://mcb.asm.org/content/31/23/4676.long

Saporita A.J., Chang H-C., Winkeler C.L., Apicelli A.J., Kladney R., Wang J.C., Townsend R.R., Michel L.S., and Weber J.D. (2011).  RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.  Cancer Research, 71: 6708-17.
http://cancerres.aacrjournals.org/content/71/21/6708.long

Olanich M.E., Moss B.L., Townsend R.R., Piwnica-Worms D., and Weber J.D. (2011).  Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation.  Oncogene, 30: 77-86.
http://www.nature.com/onc/journal/v30/n1/full/onc2010404a.html

Rauch D.A., Hurchla M.A., Harding J.C., Deng H., Shea L.K., Eagleton M.C., Niewiesk S., Lairmore M.D., Piwnica-Worms D., Rosol T.J., Weber J.D., Ratner L., and Weilbaecher K.N. (2010).  The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.  PLoS One, 5: e15755.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015755

Kladney R.D., Cardiff R.D., Kwiatkowski D.J., Chiang G.G., Weber J.D., Arbeit J.M., and Lu Z.H. (2010). TSC1 Is an epithelial tumor suppressor that is essential to prevent spontaneous prostate cancer in aged mice.  Cancer Research, 70: 8937-8947.
http://cancerres.aacrjournals.org/content/70/21/8937.long

Dong Y., Li A., Wang J., Weber J.D., and Michel L.S. (2010).  Synthetic lethality through combined notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer.  Cancer Research, 70: 5465-74.
http://cancerres.aacrjournals.org/content/70/13/5465.long

Abella N., Brun S., Calvo M., Tapia O., Weber J.D., Berciano M.T., Lafarga M., Bachs O., and Agell N. (2010).  Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage. Traffic, 11: 743-55.
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0854.2010.01063.x/abstract;jsessionid=3F791BEEE48E35E881937C7B5705C79B.f01t02

Crowder R.J., Phommaly C., Tao Y., Hoog J., Luo J., Perou C.M., Parker J., Miller M.A., Huntsman D.G., Lin L., Snider J., Davies S.R., Olson J., Watson M.A., Saporita A.J., Weber J.D. and Ellis M. (2009).  PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor positive breast cancer.  Cancer Research, 69: 3955-62.
http://cancerres.aacrjournals.org/content/69/9/3955.long

Vanderwaal R.P., Maggi L.B., Weber J.D., Hunt C.R. and Roti Roti J.L. (2009).   Nucleophosmin redistribution following heat shock: a role in heat-induced radiosensitization.  Cancer Research, 69: 6454-6462.
http://cancerres.aacrjournals.org/content/69/16/6454.long

Brady S.N., Maggi L.B., Winkeler C.L., Toso E.A., Gwinn A.S., Pelletier C.L. and Weber J.D.  (2009).   Threonine 198 phosphorylation is dispensable for nucleophosmin’s essential roles in growth and proliferation.  Oncogene, 28: 3209-3220.
http://www.nature.com/onc/journal/v28/n36/full/onc2009178a.html

Maggi L.B., Kuchenreuther M., Dadey D.Y., Schwope R.M., Grisendi S., Townsend R.R., Pandolfi P.P. and Weber J.D. (2008).  Nucleophosmin serves as a rate-limiting nuclear export chaperone for the mammalian ribosome.  Molecular and Cellular Biology, 28: 7050-7065.
http://mcb.asm.org/content/28/23/7050.long

Apicelli A.J., Maggi, L.B., Hirbe A.C., Miceli, A.P., Olanich, M., Schulte-Winkeler, C.L., Saporita, A.J., Kuchenreuther, M., Sanchez, J., Weilbaecher K.N. and Weber J.D. (2008). A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function.  Molecular and Cellular Biology, 28: 1068-1080.
http://mcb.asm.org/content/28/3/1068.long

Sandsmark D.K., Pelletier C.L., Weber J.D. and Gutmann D.H. (2007).  Mammalian target of rapamycin: Master regulator of growth in the nervous system. Histology and Histopathology, 22:895-903.
http://www.hh.um.es/Abstracts/Vol_22/22_8/22_8_895.htm

Saporita, A.J., Maggi, L.B., Apicelli A.J. and Weber J.D. (2007).  Therapeutic targets in the ARF tumor suppressor pathway.  Current Medicinal Chemistry, 14:1815-27.
http://www.eurekaselect.com/59506/article

Wong, S. and Weber, J.D. (2007). Deacetylation of the Rb tumor suppressor protein by Sirt1.  Biochemical Journal, 407: 451-60.
http://www.biochemj.org/bj/407/0451/bj4070451.htm

Takeshita S., Faccio R., Chappel J., Zheng L., Feng X., Weber J.D., Teitelbaum S.L. and Ross F.P. (2007).  C-FMS tyrosine 559 is a major mediator of M-CSF induced proliferation of primary macrophages. Journal of Biological Chemistry, 282: 18980-90.
http://www.jbc.org/content/282/26/18980.long

Sandsmark D.K., Zhang H., Hegedus B., Pelletier C.L., Weber J.D. and Gutmann D.H. (2007).  Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes. Cancer Research, 67: 4790-9.
http://cancerres.aacrjournals.org/content/67/10/4790.long

Pelletier, C.L., Maggi, L.B., Scheidenhelm, D.K., Gutmann, D.H. and Weber J.D. (2007).  TSC1 sets the rate of ribosome nuclear export and protein synthesis through nucleophosmin translation. Cancer Research, 67: 1609-1617.
http://cancerres.aacrjournals.org/content/67/4/1609.long

Lin, D.I., Barbash, O., Kumar, K.G.S., Weber, J.D., Elledge, S.J., Harper, J.W., Klein-Szanto, A.J.P., Rustgi, A., Fuchs, S. and Diehl, J.A. (2006). Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-crystallin complex. Molecular Cell, 24: 355-66.
http://www.sciencedirect.com/science/article/pii/S1097276506006356

Yu Y., Maggi L.B., Brady S.N., Apicelli A.J., Dai M., Lu H. and Weber J.D. (2006).  Nucleophosmin is essential for ribosomal protein L5 nuclear export.  Molecular and Cellular Biology 26: 3798-3809.
http://mcb.asm.org/content/26/10/3798.long

Keller P.C., Tomita T., Hayashi I., Chandu D., Weber J.D., Cistola D.P. and Kopan R. (2006).  A faster migrating variant masquerades as NICD when performing in vitro -secretase assays with bacterially expressed Notch substrates. Biochemistry, 45: 5351-5358.
http://pubs.acs.org/doi/abs/10.1021/bi052228a

Maggi, L.B. and Weber, J.D. (2005).  Nucleolar adaptation in human cancers. Cancer Investigation 23: 599-608.
http://informahealthcare.com/doi/abs/10.1080/07357900500283085

Dasgupta B., Yi Y., Hegedus B., Weber J.D. and Gutmann D.H. (2005). Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.  Cancer Research 65: 9801-9808.
http://cancerres.aacrjournals.org/content/65/21/9843.long

Dasgupta, B., Yi, Y., Chen, D.A., Weber, J.D. and Gutmann, D.H. (2005). Proteomic analysis reveals hyperactivation of the mTOR pathway in NF1-associated human and mouse brain tumors.  Cancer Research, 65: 2755-2760.
http://cancerres.aacrjournals.org/content/65/7/2755.long

Brady, S., Yu, Y., Maggi, L.B. and Weber, J.D. (2004).  ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway.  Molecular & Cellular Biology, 24: 9327-9338.
http://mcb.asm.org/content/24/21/9327.long