Weber Lab Publications

Kung C.P., Cottrell K.A., Ryu S., Bramel E.R., Kladney R.D., Bao E.A., Freeman E.C., Sabloak T., Maggi L.B. and Weber J.D. (2021). Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer. Oncogene, 40:189-202.

Cho B., Han Y., Lian M., Colditz G.A., Weber J.D., Ma C. and Liu Y. (2021). Evaluation of racial/ethnic differences in treatment and mortality among women with triple-negative breast cancer. JAMA Oncology, 7:1016-1023.

Cottrell K.A., Chiou R.C. and Weber J.D. (2020). Upregulation of 5’-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor. Scientific Reports, 10:22276-89.

Dania V., Liu Y., Ademuyiwa F., Weber J.D. and Colditz G.A. (2019). Associations of race and ethnicity with risk of developing invasive breast cancer after lobular carcinoma in situ. Breast Cancer Research, 21:120-126.

Liu Y., West R., Weber J.D., and Colditz G.A. (2019). Race and risk of subsequent aggressive breast cancer following ductal carcinoma in situ. Cancer, 125:3225-3233.

Wang J. Yuan Z., Weber J.D., and Zhang Y. (2019). DHX33 interacts with AP-2b to regulat gene expression and promote cancer cell survival. Molecular and Cellular Biology, 39:e00017-19.

Yao C.H., Wang R., Wang Y., Kung C.P., Weber J.D., and Patti G.P (2019). Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation, eLife, e41351:1-19.

Kung C.P, Maggi L.B., and Weber J.D. (2018). The role of RNA editing in cancer development and metabolic disorders. Frontiers in Endocrinology, eCollection.

Wagner A.H., Devarakonda S., Skidmore Z.L., Krysiak K., Ramu A., Trani J., Masood A., Waqar S.N., Spies N.C., Morgensztern D., Waligorski J., Ponce J., Fulton R.S., Maggi L.B., Weber J.D., Watson M.A., O’Connor C.J., Cheng H., Cessna M.H., Oliver T.G., Mardis E.R., Wilson R.K., Griffith M., Griffith, O.L and Govindan R. (2018). Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. Nature Communications, 9:3787-3798.

Mahajan N., Wu H-J., Bennett R.L., Troche C., Licht J.D., Weber J.D., Maggi L.B. and Tomasson M.H. (2017). Sabotaging of the oxidative stress response by an oncogenic non-coding RNA. FASEB Journal, 31:482-90.

Yuan B., Wang X., Fan C., Yu J., Liu Y. Weber J.D., Zongand H., and Zhang Y. (2016). DHX33 transcriptionally controls genes involved in cell cycle. Molecular and Cellular Biology, in press.

Weber J.D., Yarden Y., Dustin M., Sassoon D.A., and Ezekowitz A. (2015). Functional Cell Biology: An Overview. Encyclopedia of Cell Biology, 3: 1-7, Waltham, MA: Academic Press.

Maggi L.B. and Weber J.D. (2015). Targeting PTEN-deficient breast cancers with a one-two punch. Breast Cancer Research, 17:51-52.

Zhang Y., You J., Wang X., and Weber J.D. (2015). The DHX33 RNA helicase promotes mRNA translation initiation. Molecular and Cellular Biology, 35:2918-31.

Zhang Y., Baysac K.C., Yee L.F., Saporita A.J., and Weber J.D. (2014). Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers. Breast Cancer Research, 16:449-467.

Govindan R. and Weber J.D. (2014) TP53 mutations and lung cancer: not all mutations are created equal. Clinical Cancer Research, 20:4419-21.

Maggi, L.B., Winkeler C.L., Miceli A.P., Brady S.N., Kuchenreuther M.J., and Weber J.D. (2014).  ARF tumor suppression in the nucleolus.  Biochimica et Biophysica Acta, 1842:831-839.

Forys J.T., Kuzmicki C.E., Saporita A.J., Winkeler C.L., Maggi L.B., and Weber J.D. (2014).  Arf and p53 coordinate tumor suppression of an oncogenic IFN--STAT1-ISG15 signaling axis.  Cell Reports, 7:514-26.

Kuchenruether M.J. and Weber J.D. (2014).  The ARF tumor suppressor controls Drosha translation to prevent Ras-driven transformation.  Oncogene, 33: 300-307.

Maggi L.B. and Weber J.D. (2013).  Forget transcription: translation is where the action is.  Molecular and Cellular Biology, 33:1884-5.

Chang C.H., Curtis J.D., Maggi L.B., Faubert B., Villarino A.V., O’Sullivan D., Huang S.C., van der Windt G.J., Blagih J., Qiu J. Weber J.D., Pearce E.J., Jones R.G. and Pearce E.L. (2013).  Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell, 153: 1239-51.

Zhong H., Sanchez C., Spitrzer D., Plambeck-Suess S., Gibbs J., Hawkins W.G., Denardo, D. Gao F., Pufahl R.A., Lockhart A.C., Xu M., Linehan D., Weber J.D., and Wang-Gillam A. (2013). Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models. PLoS One, 8: e77243.

Zhang Y., Saporita A.J., and Weber J.D. (2013). P19ARF and RasV12 offer opposing regulation of DHX33 translation to dictate tumor cell fate.  Molecular and Cellular Biology, 33: 1594-607.

Winkeler C.L., Kladney R.D., Maggi L.B. and Weber J.D. (2012).  Cathepsin K-Cre causes unexpected germline deletion of genes in mice.  PLoS One, 7: e42005.

Ellis, M.J. et al. (2012).  Whole-genome analysis informs breast cancer response to aromatase inhibition.  Nature, 486: 353-360.

Xu Z., Joshi N., Agarwal A., Dahiya S., Bittner P., Smith E., Taylor S., Piwnica-Worms D., Weber J.D. and Leonard J.R. (2012).  Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest.  Journal of Neurooncology, 108: 59-67.

Weber J.D. and Gutmann D.H. (2012).  Deconvoluting mTOR biology.  Cell Cycle, 11: 236-48.

Miceli A.P., Saporita A.J., and Weber J.D. (2012).  Hyper-growth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint.  Molecular and Cellular Biology, 32: 348-64.

Wang J., Zhang K., Grabowska D., Li A., Dong Y., Day R., Humphrey P., Lewis J.S., Kladney R., Arbeit J.M., Weber J.D., Chung C.H. and Michel L.S. (2011).  Loss of Trop2 promotes carcinogenesis and features of epithelial to mesenchymal transition in squamous cell carcinoma.  Molecular Cancer Research, 9: 1686-95.

Zhang Y., Forys J.T., Miceli A.P., Gwinn A.S. and Weber J.D. (2011).  Identification of DHX33 as a mediator of rRNA synthesis and cell growth.  Molecular and Cellular Biology, 31: 4676-91.

Saporita A.J., Chang H-C., Winkeler C.L., Apicelli A.J., Kladney R., Wang J.C., Townsend R.R., Michel L.S., and Weber J.D. (2011).  RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.  Cancer Research, 71: 6708-17.

Olanich M.E., Moss B.L., Townsend R.R., Piwnica-Worms D., and Weber J.D. (2011).  Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation.  Oncogene, 30: 77-86.

Rauch D.A., Hurchla M.A., Harding J.C., Deng H., Shea L.K., Eagleton M.C., Niewiesk S., Lairmore M.D., Piwnica-Worms D., Rosol T.J., Weber J.D., Ratner L., and Weilbaecher K.N. (2010).  The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.  PLoS One, 5: e15755.

Kladney R.D., Cardiff R.D., Kwiatkowski D.J., Chiang G.G., Weber J.D., Arbeit J.M., and Lu Z.H. (2010). TSC1 Is an epithelial tumor suppressor that is essential to prevent spontaneous prostate cancer in aged mice.  Cancer Research, 70: 8937-8947.

Dong Y., Li A., Wang J., Weber J.D., and Michel L.S. (2010).  Synthetic lethality through combined notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer.  Cancer Research, 70: 5465-74.

Abella N., Brun S., Calvo M., Tapia O., Weber J.D., Berciano M.T., Lafarga M., Bachs O., and Agell N. (2010).  Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage. Traffic, 11: 743-55.;jsessionid=3F791BEEE48E35E881937C7B5705C79B.f01t02

Crowder R.J., Phommaly C., Tao Y., Hoog J., Luo J., Perou C.M., Parker J., Miller M.A., Huntsman D.G., Lin L., Snider J., Davies S.R., Olson J., Watson M.A., Saporita A.J., Weber J.D. and Ellis M. (2009).  PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor positive breast cancer.  Cancer Research, 69: 3955-62.

Vanderwaal R.P., Maggi L.B., Weber J.D., Hunt C.R. and Roti Roti J.L. (2009).   Nucleophosmin redistribution following heat shock: a role in heat-induced radiosensitization.  Cancer Research, 69: 6454-6462.

Brady S.N., Maggi L.B., Winkeler C.L., Toso E.A., Gwinn A.S., Pelletier C.L. and Weber J.D.  (2009).   Threonine 198 phosphorylation is dispensable for nucleophosmin’s essential roles in growth and proliferation.  Oncogene, 28: 3209-3220.

Maggi L.B., Kuchenreuther M., Dadey D.Y., Schwope R.M., Grisendi S., Townsend R.R., Pandolfi P.P. and Weber J.D. (2008).  Nucleophosmin serves as a rate-limiting nuclear export chaperone for the mammalian ribosome.  Molecular and Cellular Biology, 28: 7050-7065.

Apicelli A.J., Maggi, L.B., Hirbe A.C., Miceli, A.P., Olanich, M., Schulte-Winkeler, C.L., Saporita, A.J., Kuchenreuther, M., Sanchez, J., Weilbaecher K.N. and Weber J.D. (2008). A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function.  Molecular and Cellular Biology, 28: 1068-1080.

Sandsmark D.K., Pelletier C.L., Weber J.D. and Gutmann D.H. (2007).  Mammalian target of rapamycin: Master regulator of growth in the nervous system. Histology and Histopathology, 22:895-903.

Saporita, A.J., Maggi, L.B., Apicelli A.J. and Weber J.D. (2007).  Therapeutic targets in the ARF tumor suppressor pathway.  Current Medicinal Chemistry, 14:1815-27.

Wong, S. and Weber, J.D. (2007). Deacetylation of the Rb tumor suppressor protein by Sirt1.  Biochemical Journal, 407: 451-60.

Takeshita S., Faccio R., Chappel J., Zheng L., Feng X., Weber J.D., Teitelbaum S.L. and Ross F.P. (2007).  C-FMS tyrosine 559 is a major mediator of M-CSF induced proliferation of primary macrophages. Journal of Biological Chemistry, 282: 18980-90.

Sandsmark D.K., Zhang H., Hegedus B., Pelletier C.L., Weber J.D. and Gutmann D.H. (2007).  Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes. Cancer Research, 67: 4790-9.

Pelletier, C.L., Maggi, L.B., Scheidenhelm, D.K., Gutmann, D.H. and Weber J.D. (2007).  TSC1 sets the rate of ribosome nuclear export and protein synthesis through nucleophosmin translation. Cancer Research, 67: 1609-1617.

Lin, D.I., Barbash, O., Kumar, K.G.S., Weber, J.D., Elledge, S.J., Harper, J.W., Klein-Szanto, A.J.P., Rustgi, A., Fuchs, S. and Diehl, J.A. (2006). Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-crystallin complex. Molecular Cell, 24: 355-66.

Yu Y., Maggi L.B., Brady S.N., Apicelli A.J., Dai M., Lu H. and Weber J.D. (2006).  Nucleophosmin is essential for ribosomal protein L5 nuclear export.  Molecular and Cellular Biology 26: 3798-3809.

Keller P.C., Tomita T., Hayashi I., Chandu D., Weber J.D., Cistola D.P. and Kopan R. (2006).  A faster migrating variant masquerades as NICD when performing in vitro -secretase assays with bacterially expressed Notch substrates. Biochemistry, 45: 5351-5358.

Maggi, L.B. and Weber, J.D. (2005).  Nucleolar adaptation in human cancers. Cancer Investigation 23: 599-608.

Dasgupta B., Yi Y., Hegedus B., Weber J.D. and Gutmann D.H. (2005). Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.  Cancer Research 65: 9801-9808.

Dasgupta, B., Yi, Y., Chen, D.A., Weber, J.D. and Gutmann, D.H. (2005). Proteomic analysis reveals hyperactivation of the mTOR pathway in NF1-associated human and mouse brain tumors.  Cancer Research, 65: 2755-2760.

Brady, S., Yu, Y., Maggi, L.B. and Weber, J.D. (2004).  ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway.  Molecular & Cellular Biology, 24: 9327-9338.