Stewart Lab Publications

Peer Reviewed

Thangavel, S., Berti, M., Levikova, M., Pinto, C., Gomathinavagam, S., Vujanovic, M., Zellweger, R., Moore, H., Lee, E.H., Hendrickson, E.A., Ceika, P., Stewart, S., Lopes, M., Vindigni, A.  Dna2 drives processing and restart of reversed replication forks in human cells.  J. Cell Biol. 208(5):545-62.  2015. PMCID: PMC4347643.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347643/pdf/JCB_201406100.pdf

 

Alspach, E. and Stewart, S. A.  RNA-binding Protein Immunoprecipitation (RIP) to Examine AUF1 Binding to Senescence Associated Secretory Phenotype (SASP) Factor mRNA.  Bio Protoc. 5(10);e1481.  2015.  PMCID: PMC4957555.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957555/pdf/nihms769517.pdf

 

Teasley, D, Parajuli, S, and Stewart, S. A.  Flap endonuclease 1 limits telomere fragility on the leading strand.  JBC. 290(24):15133-45.  2015.  PMID: 25922071.

http://www.jbc.org/content/290/24/15133.full

 

Luo, X*., Fu, Y*., Loza, A., Murali, B., Leahy, K., Ruhland, M.K., Gang, M., Su, X., Zamani, A., Shu, Y., Lavine, K.J., Orntiz, D.M., Weilbaecher, K.N., Long, F., Novack, D., Faccio, F., Longmore, G., and Stewart, S. A.  Luo X, Fu, Y., Ruhland MK, Faacio, R., Stewart S. A. Stromal-initiated changes in the bone promote metastatic niche development.  Cell Reports 14(1):82-92.  2016.  PMID: 26725121.

https://www.sciencedirect.com/science/article/pii/S2211124715014291?via%3Dihub

 

D’Amico, L., Mahajan, S., Capietto, A-H., Yang, Z., Zamani, A., Ricci, B., Bumpass, D. B., Meyer, M., Su, X., Wang-Gillam, A., Weilbaecher, K., Stewart, S. A., DeNardo, D., and Faccio, R.  Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer.  .  J. Ex. Med. 213(5):827-40.  2016.  PMID: 27045006.

http://jem.rupress.org/content/213/5/827.long

 

Ruhland, M. K., Luo, X., Capietto, A-H, Loza, A., Alspach, E., Leahy, K, Belt, B., Schaffer, A., Longmore, G., Faccio, F., and Stewart, S. A.  Stromal senescence drives tumor promotion through the establishment of an immunosuppressive microenvironment.  Nat Comm. 8;7:11762.  2016.  PMID: 27272654.

https://www.nature.com/articles/ncomms11762

 

Marsh, T., Wong I., Sceneay, J., Barakat, A., Qin, Y., Sjödin, A., Alspach, E., Nilsson, B., Stewart, S. A., and McAllister, S. S.  Aging reduces the pro-tumorigenic potential of bone marrow cells and influences triple-negative breast cancer progression.  Can Res.  76(10):2932-43.  2016. PMID: 27197230.

http://cancerres.aacrjournals.org/content/76/10/2932

 

Poppler, L., Ee, X., Newton, P., Schellhardt, L., Hoben, G., Pan, D., Hunter, D., Yan, Y., Moore, A., A Synder-Warwick, A., Stewart, S. A., Mackinnon, S., and Wood., M. Axonal growth arrests after an increased accumulation of Schwann cells expressing senescence markers and stromal cells in acellular nerve allografts.  Tiss. Eng. Part A.  22(13-14):949-61.  2016. PMID: 27297909.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948214/

 

Parajuli, S., Teasley, D. C., Jackson, J., Vindigni, A., Stewart, S.A.  Human RNaseH1 limits R loops and facilitates DNA replication.  J. Biol. Chem. 292(37):15216-15224.  2017. PMID: 28717002

http://www.jbc.org/content/292/37/15216.full

 

Flanagan, K. C., Alspach, E., and Stewart, S. A.  A role for cmyb in SASP activation. Oncotarget.  9:21-36.  2018.

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=22940&path[]=72404

 

Murali, B., Ren, Q., Luo, X., Faget, D., Wang, C., Johnson, R. M., Gruosso, T., Flanagan, K., Fu, Y., Leahy, K., Alspach, E., Su., X., Ross, M. H., Burneete, B., Weilbaecher, K. N., Park, M., Mbalaviele, G., Monahan, J., Stewart S. A.  Inhibition of the stromal p38MAPK/MK2 pathway limits breast cancer metastases and chemotherapy-induced bone loss.  Cancer Research.   In press.  2018

http://cancerres.aacrjournals.org/content/early/2018/08/08/0008-5472.CAN-18-0234

 

Alspach, E., Flanagan, K. C., Huang, H., Pazolli, E., Donlin, M., and Stewart, S. A.  p38MAPK-AUF1 plays a crucial role in stromal-mediated tumorigenesis. Can. Dis. 4:716-729.  2014.  PMCID: PMC4049323.
http://cancerdiscovery.aacrjournals.org/content/4/6/716.long

Saheb-Al-Zamani M, Yan Y, Farber SJ, Hunter DA, Newton P, Wood MD, Stewart SA, Johnson PJ, Mackinnon SE.  Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence.  Exp. Neurol. 247:165-77.  2013.  PMCID: PMC3863361.
http://www.sciencedirect.com/science/article/pii/S0014488613001398

Karanja KK, Cox SW, Duxin JP, Stewart SA, Campbell JL.  DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network.  Cell Cycle 11(21):3983-96.  2013.  PMID: 22987153.
https://www.landesbioscience.com/journals/cc/article/22215/

Lee S, Stewart S, Nagtegaal I, Luo J, Wu Y, Colditz G, Medina D, Allred DC. Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer.  Cancer Res. 72(17):4574-4586.  2012.  PMCID: PMC3899801.
http://cancerres.aacrjournals.org/content/72/17/4574.long

Duxin JP, Moore HR, Sidorova J, Karanja K, Honaker Y, Dao B, Piwnica-Worms H, Campbell JL, Monnat RJ Jr, Stewart SA.  An Okazaki fragment processing-independent role for human Dna2 during DNA replication.  J Biol Chem. 287(26):21980-91.  2012.  PMID: 22570476.
http://www.jbc.org/content/287/26/21980.long

Pazolli, E., Alspach, E., Milczarek, A. Julie Prior, David Piwnica-Worms and Stewart, S. A.  Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression.  Cancer Res. 72(9):2251-61.  2012.  PMCID: PMC3605047.  
http://cancerres.aacrjournals.org/content/72/9/2251.long

Luo X, Ruhland MK, Pazolli E, Lind AC, Stewart SA.  Senescent-associated Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway.  Mol. Can. Res. 9:1018-1029.  2011.  PMID: 21673011.
http://mcr.aacrjournals.org/content/9/8/1018.long

Saharia, A., Teasley, D. C., Chiappinelli, K. B., Dao, B., and Stewart, S. A.  FEN1 ensures telomere stability by facilitating replication fork re-initiation. JBC 285(35):27057-66.  2010.  PMID: 20551483.  
http://www.jbc.org/content/285/35/27057.long

Nittis, T, Guittat, G, LeDuc, Dao, B., Duxin, J.P., R. D., Rohrs, H., Townsend, R. R., and Stewart, S.A.  Revealing the telomeric interactome through label-free comparative LC-MS.  Mol Cell Proteomics.  9:1144-1156.  2010.
http://www.mcponline.org/content/9/6/1144.long

Duxin, J. P., Dao, B., Martinsson, P., Rajala, N., Guittat, L., Campbell, J. L., Spelbrink, J. N., and Stewart, S. A.  Human DNA2 is a nuclear and mitochondrial maintenance protein.  Mol. Cell. Biol. 29(15): 4274-82.  2009.  
http://mcb.asm.org/content/29/15/4274.long

Saharia, A. and Stewart, S. A.  FEN1 loss in cancer cells leads to telomere dysfunction.  Oncogene 28(8):1162-7.  2009.
http://www.nature.com/onc/journal/v28/n8/full/onc2008458a.html 

Pazolli, E., Luo, L., Brehm, S., Carbery, K., Chung, J-J.,  Prior, J. L., Doherty, J., Demehri, S., Salavaggione, Lorena, Piwnica-Worms, D., and Stewart, S. A. Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth.  Cancer Research 69(3):1230-1239.  2009.  PMID: 19155301.  
http://cancerres.aacrjournals.org/content/69/3/1230.long

Nystrom, A. M., Xu, Z., Xu, J., Taylor, S., Nittis, T., Stewart, S. A., and Wooley, K. L.  SCKs as nanoparticle carriers of doxorubicin: Investigation of core composition on the loading, release and cytotoxicity profiles.  Chem Comm. 30:3579-81.  2008.  PMCID: PMC2828943.
http://pubs.rsc.org/en/Content/ArticleLanding/2008/CC/b805428b#!divAbstract

Saharia, A., Guittat, L., Crocker S, Lim A, Steffen M, Kulkarni S, and Stewart, S. A.  Flap Endonuclease I contributes to telomere stability.  Current Biology 18(7): 496-500.  2008.  PMID: 20097687.  
http://www.sciencedirect.com/science/article/pii/S0960982208002583

Moffat, J, Grueneberg, D. A., Yang, X., Kim, S. Y., Kloepfer, A. M., Hinkle, G., Piqani, B., Eisenhaure, T. M., Luo, B., Grenier, J. K., Carpenter, a. E., Foo, S. Y., Stewart, S. A., Stockwell, B. R., Hacohen, N., Hahn, W. C., Lander, E. S., Sabatini, D. M., Root, D. E.  A lentiviral RNAi library for human and mouse genes: Construction, characterization and application to an arrayed screen.  Cell 124: 1283-1298.  2006.
http://www.sciencedirect.com/science/article/pii/S0092867406002388

Zaehres, H., Lensch, M.W., Daheron, L., Stewart, S.A., Itskovitz-Eldor, J, Daley, G.Q.  High-efficiency RNA interference in human embryonic stem cells.  Stem Cells. 23(3):299-305.  2005.
http://onlinelibrary.wiley.com/doi/10.1634/stemcells.2004-0252/abstract;jsessionid=3A61D884C055928B7701CCF17951EF51.f02t02

 

Recent Reviews

Alspach, E., Fu, Y., and Stewart, S. A.  Aging and the tumor microenvironment.  Critical Reviews in Oncogenesis 18(6): 549-558.  PMCID: PMC3951899.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951899/

Stewart, S. A. and Berturch, A.  Meeting Report: The Role of Telomeres and Telomerase in Cancer Research.  Can. Res. 70(9): 7365-7371.  2010.
http://cancerres.aacrjournals.org/content/70/19/7365.long

Pazolli, E. and Stewart, S. A. Senescence: the good, the bad and the dysfunctional. Curr. Opin. Gen. & Dev. 18:1-6.  2008.
http://www.sciencedirect.com/science/article/pii/S0959437X07002122

Nittis T, Guittat L, Stewart S. A.  Alternative lengthening of telomeres (ALT) and chromatin: is there a connection? Biochimie. Jan;90(1):5-12.  2008.
http://www.sciencedirect.com/science/article/pii/S0300908407002234

Stewart, S. A. and Weinberg, R. A.  Telomeres: Cancer to human aging.  Annu. Rev. Cell Dev. Biol. 22:531-57.  2006.
http://www.annualreviews.org/doi/full/10.1146/annurev.cellbio.22.010305.104518?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Stewart, S. A.  Telomere maintenance and tumorigenesis: an “ATL”ernative road.  Curr. Mol. Med 5:253-257.  2005.  
http://www.eurekaselect.com/61504/article

Stewart, S. A.  Multiple levels of telomerase regulation.  Mol. Interven. 2(8):481-483.  2002.
http://www.ncbi.nlm.nih.gov/pubmed/14993399