Chheda Lab Publications

Chheda MG, Wen PY, Hochberg FH, Chi AS, Drappatz J, Eichler AF, Yang D,
Beroukhim R, Norden AD, Gerstner ER, Betensky RA, Batchelor TT. Vandetanib plus
sirolimus in adults with recurrent glioblastoma: results of a phase I and dose
expansion cohort study. J Neurooncol. 2015 Feb;121(3):627-34. doi:
10.1007/s11060-014-1680-2. Epub 2014 Dec 13. PubMed PMID: 25503302; PubMed
Central PMCID: PMC4324090.

Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen
MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J,
Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A,
Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG.
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma
tumor-initiating cell state. Cell Rep. 2014 Jan 30;6(2):313-24. doi:
10.1016/j.celrep.2013.12.032. Epub 2014 Jan 16. PubMed PMID: 24440720; PubMed
Central PMCID: PMC4041390.

Quayle SN, Chheda MG, Shukla SA, Wiedemeyer R, Tamayo P, Dewan RW, Zhuang L,
Huang-Hobbs E, Haidar S, Xiao Y, Ligon KL, Hahn WC, Chin L. Integrative
functional genomics identifies RINT1 as a novel GBM oncogene. Neuro Oncol. 2012
Nov;14(11):1325-31. doi: 10.1093/neuonc/nos246. Epub 2012 Oct 16. PubMed PMID:
23074196; PubMed Central PMCID: PMC3480269.

Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK,
Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho
RA, Chin L, Hahn WC. Emerging insights into the molecular and cellular basis of
glioblastoma. Genes Dev. 2012 Apr 15;26(8):756-84. doi: 10.1101/gad.187922.112.
Review. PubMed PMID: 22508724; PubMed Central PMCID: PMC3337451.

Zheng S, Chheda MG, Verhaak RG. Studying a complex tumor: potential and
pitfalls. Cancer J. 2012 Jan-Feb;18(1):107-14. doi:10.1097/PPO.0b013e3182431c57.
Review. PubMed PMID: 22290264; PubMed Central PMCID: PMC3342695.

Wiedemeyer WR, Dunn IF, Quayle SN, Zhang J, Chheda MG, Dunn GP, Zhuang L,
Rosenbluh J, Chen S, Xiao Y, Shapiro GI, Hahn WC, Chin L. Pattern of
retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in
GBM. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11501-6. doi:
10.1073/pnas.1001613107. Epub 2010 Jun 7. PubMed PMID: 20534551; PubMed Central
PMCID: PMC2895056.

Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H,Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. PLAGL2 regulates Wnt signaling to impede
differentiation in neural stem cells and gliomas. Cancer Cell. 2010 May
18;17(5):497-509. doi: 10.1016/j.ccr.2010.03.020. PubMed PMID: 20478531; PubMed
Central PMCID: PMC2900858.

Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH,
Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, Jain S,
Bojarski E, Mermel C, Barretina J, Chan JA, Baselga J, Tabernero J, Root DE,
Fuchs CS, Loda M, Shivdasani RA, Meyerson M, Hahn WC. CDK8 is a colorectal canceroncogene that regulates beta-catenin activity. Nature. 2008 Sep
25;455(7212):547-51. doi: 10.1038/nature07179. Epub 2008 Sep 14. PubMed PMID:
18794900; PubMed Central PMCID: PMC2587138.

Chheda MG, Drappatz J, Greenberger NJ, Kesari S, Weiss SE, Gigas DC, Doherty
LM, Wen PY. Hepatitis B reactivation during glioblastoma treatment with
temozolomide: a cautionary note. Neurology. 2007 Mar 20;68(12):955-6. PubMed
PMID: 17372135.